X-ray irradiation activates K+ channels via H2O2 signaling
نویسندگان
چکیده
منابع مشابه
X-ray irradiation activates K+ channels via H2O2 signaling
Ionizing radiation is a universal tool in tumor therapy but may also cause secondary cancers or cell invasiveness. These negative side effects could be causally related to the human-intermediate-conductance Ca2+-activated-K+-channel (hIK), which is activated by X-ray irradiation and affects cell proliferation and migration. To analyze the signaling cascade downstream of ionizing radiation we us...
متن کاملInduction of radioresistant nasopharyngeal carcinoma cell line CNE-2R by repeated high-dose X-ray irradiation
Background: All To enhance the curative effect of radiotherapy, we established a radio-resistant cell line, CNE-2R from CNE-2, a radio-sensitive type of CNE, through repeated irradiation. The developed cell line provides a basis for further studies on the radio-resistance of CNE and the molecular mechanism of radiotherapy sensitization drugs. Materials and Methods: The CNE-2 cell line was selec...
متن کاملTGFβ activates PI3K-AKT signaling via TRAF6
Deregulation of the PI3K/AKT pathway has been reported in many types of cancer, including prostate cancer. As AKT regulates survival, metabolism, migration and therapy resistance in cancer cells, aberrant, high activity of AKT is involved in poor prognosis in cancer patients [1]. Transforming growth factor-β (TGFβ) family members are important for regulation of embryogenesis and tissue homeosta...
متن کاملBlue light activates calcium-permeable channels in Arabidopsis mesophyll cells via the phototropin signaling pathway.
Light is a central regulator of plant growth and development. Among the processes triggered by blue and UV-A light, phototropism, stomatal movement, and chloroplast orientation rely on the activation of blue-light receptors known as phototropins. So far, these photoreceptors constitute a class of light receptor kinases unique to the plant kingdom. In Arabidopsis thaliana, the two members phot1 ...
متن کاملANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells.
We have previously shown that the vasoconstrictive peptide angiotensin II (ANG II) is a hypertrophic agent for human coronary artery smooth muscle cells (cSMCs), which suggests that it plays a role in vascular wall thickening. The present study investigated the intracellular signal transduction pathways involved in the growth response of cSMCs to ANG II. The stimulation of protein synthesis by ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep13861